Greenfield is located on the Deerfield River where Route 2 intersects I-91, the north-south highway through New England. Route 2 is a primary connector from Boston to New York State making this a most attractive central point in Western Massachusetts. I-91 gives Greenfield ready access to New York City and Canada, and Route 2 offers a byway into Boston to the east and Albany, New York to the west. Greenfield is also well served by rail via the Springfield Terminal Railway and the Central Vermont Railway. It is in the center of a circle of small cities that include Brattleboro in Vermont, Pittsfield, Springfield, Worcester, Leominster and Fitchburg in Massachusetts, and Keene in New Hampshire._Immediately to its south is the historic town of Deerfield and further south are the communities of Northampton and Amherst and the surrounding five colleges: Smith, Mt. Holyoke, Amherst, Hampshire Colleges and the University of Massachusetts. To the east is the Quabbin resevoir, to the west are the Berkshire Mountains, and to the north are the Green Mountains of Vermont.
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